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- Sacagawea
- Safety
- Sagan, Carl
- Sailing
- St. Augustine Historic Settlement
- St. Joseph County, Indiana
- St. Kitts-Nevis
- St. Lucia
- St. Vincent and the Grenadines
- Saint Patrick/Saint Patrick's Day
- Saints (Catholic)
- Samoa, American
- San Diego
- San Francisco
- San Marino
- Sandburg, Carl
- Sanger, Margaret
- Santa Claus
- Sao Tome & Principe
- Sargent, John Singer
- Saturn
- Saudi Arabia
- Schizophrenia
- Schools:
- Schroedinger, Erwin
- Science
- Science Museums
- Science Safety
- Scientific Method
- Scientific Notation
- Scientists & Mathematicians
- Scotland
- Scott County, Indiana
- Scouts (boy)
- SCUBA Diving
- Seals
- Selenium
- Senegal
- Separation of Church and State
- Separation Techniques, Analytical
- September 11, 2001
- Serbia and Montenegro
- Service Organizations
- Seton, Elizabeth Bayley
- Settlement Houses
- Seurat, Georges
- Seuss, Dr.
- Seven Years War
- Sewing Machine
- Sexually Transmitted Diseases
- Seychelles
- Shakespeare, William
- Sharks
- Sheep
- Ships
- Shockley, William Bradford
- Shrews
- Sibelius, Jean
- Sicily
- Sickle Cell Disorder
- Sierra Leone
- Sight
- Sign Language, American.
- Significant Digits
- Silicon
- Silk
- Sills, Beverly
- Silver
- Simple Machines
- Simulation Technology
- Singapore
- Sisley, Alfred
- Sistine Chapel
- Skating, Figure
- Skeletal System
- Skiing & Snowboarding
- Skin
- Skinner, B.F.
- Skunks
- Slave Trade
- Slavery
- Sleep
- Slocum, Frances
- Slovakia
- Slovenia
- Small Business (Starting)
- Small Pox
- Smith, Adam
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- Smith, Margaret Chase
- Smith, Vernon L.
- Smithies, Oliver
- Smoot, George F.
- Snails
- Snakes
- Snow
- Soap
- Soccer
- Social Studies
- Socrates
- Sodium
- Soils & Rock
- Solar Energy
- Solar Flares
- The Solar System
- The Solomon Islands
- The Solstice
- Solutions
- Somalia
- Sound
- South Africa
- South America
- South Carolina
- South Dakota
- South Dakota
- Southeast United States
- Soviet Union
- Space
- Space Exploration
- Space Planes
- The Space Shuttle
- Space Station, International
- Spain
- Spain, New
- Spanish-American War
- Spanish Armada, Defeat of
- Spanish Civil War
- Spanish Conquest
- Spanish Language
- Special Needs Education
- Spectroscopy
- Speech
- Speech Disorders
- Speed Skating
- Spencer County, Indiana
- Spenser, Edmund
- Spiders
- Spinoza, Benedict de
- Sports (Competitive)
- Sports Medicine
- Spring (season)
- Sri Lanka
- Stage/Theater
- Stamp Act of 1765
- Stamp Collecting
- Standard Oil
- Standards of Measurement
- Stanton, Elizabeth Cady
- The Star Spangled Banner
- Starke County, Indiana
- Stars & Constellations
- States' Rights
- Statistics & Probability
- Steam Engine
- Steamboats
- Steinbeck, John
- Steinem, Gloria
- Stevens, Wallace
- Stevenson, Robert Louis
- Stine, R.L.
- Stoichiometry
- Storms
- Storytelling and Commentary
- Stowe, Harriet Beecher
- Stratton-Porter, Gene
- String Theory
- Stroke
- Structural Design
- Student Rights
- Student Tools:
- Style Guides
- Sub-Atomic Particles
- Submarines
- Substance Abuse
- Success & Leadership
- Sudan
- Sudoku
- The Suez Canal
- Suffrage, Women's
- Suicide
- Sulston, John E.
- Sumatra
- The Sun
- Superconductivity
- Supreme Court, U.S.
- Surfing
- Suriname
- Survival Skills (outdoor)
- Swaziland
- Sweden/Swedish Language
- Swimming
- Switzerland
- Symmetry
- Syria
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